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Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism

✍ Scribed by Anke-Hilse Maitland-van der Zee; Bruno H.Ch Stricker; Olaf H Klungel; John J.P Kastelein; Albert Hofman; Jacqueline C.M Witteman; Hubertus G.M Leufkens; Cornelia M.van Duijn; Anthonius de Boer

Book ID
118420365
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
43 KB
Volume
175
Category
Article
ISSN
0021-9150

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✍ Luis A. Salazar; Mario H. Hirata; Γ‰der C.R. QuintΓ£o; Rosario D.C. Hirata πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 63 KB πŸ‘ 2 views

Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron