Second-trimester maternal serum screening for fetal Down's syndrome is well established in many Western countries. Its usefulness and acceptability is unknown in the Asian countries. Between June 1994 and December 1996, we offered second-trimester serum AFP and hCG screening to pregnant women in Hon
Effectiveness of combining maternal serum alpha-fetoprotein and hCg in a second-trimester screening program for down syndrome
โ Scribed by Matthew J. Werner
- Book ID
- 116038905
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1995
- Tongue
- English
- Weight
- 100 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0029-7844
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๐ SIMILAR VOLUMES
High free beta human chorionic gonadotropin ( -hCG) and low alpha-fetoprotein (AFP) levels were found in 47 Asian Down's syndrome pregnancies (median values 2โข79 and 0โข77 MOM, respectively). At a 5 per cent false-positive rate, free -hCG alone would identify 46โข8 per cent of Down's syndrome pregnanc
To assess the value of inhibin A as an additional second-trimester maternal serum marker of Down's syndrome we studied 56 affected and 280 unaffected pregnancies matched for gestational age. The median level in the cases was 1.62 multiples of the gestation-specific median (MOM) in the controls, with
Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We meas