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Effective treatment of orthostatic tremor with gabapentin

✍ Scribed by Virgilio Gerald H. Evidente; Charles H. Adler; John N. Caviness; Katrina A. Gwinn

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
324 KB
Volume
13
Category
Article
ISSN
0885-3185

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✦ Synopsis

We report seven patients with orthostatic tremor (OT) who were successfully treated with the anticonvulsant gabapentin. Five of the patients had been previously tried on clonazepam, the most commonly used drug for OT, four without any benefit. The degree of improvement perceived by the patients with gabapentin varied from 60-80% (mean 73%). The effective dose of gabapentin ranged from 300-1800 mg/day (mean 1030 mg/day). The side effects were generally mild, transient, and dose-related. Duration of response has so far ranged from 2-22 months (mean 11 months) with all patients still currently benefiting from gabapentin. We conclude that gabapentin may be an effective treatment for OT. Further trials are indicated.

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