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Effective treatment of active Crohn's disease with humanized monoclonal antibody MRA to interleukin-6 receptor: A randomized placebo-controlled trial

✍ Scribed by Hiroaki Ito; Masakazu Takazoe; Yoshihiro Fukuda; Toshifumi Hibi; Kazuo Kusugami; Akira Andoh; Takayuki Matsumoto; Takehira Yamamura; Junichi Azuma; Norihiro Nishimoto; Kazuyuki Yoshizaki; Takashi Shimoyama; Tadamitsu Kishimoto


Book ID
119426983
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
103 KB
Volume
124
Category
Article
ISSN
0016-5085

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Treatment of rheumatoid arthritis with h
✍ Norihiro Nishimoto; Kazuyuki Yoshizaki; Nobuyuki Miyasaka; Kazuhiko Yamamoto; Sh πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 163 KB πŸ‘ 3 views

## Abstract ## Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response, inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in rheumatoid arthritis (RA), and the blockade of IL‐6 may be therapeutically effective for the disease. This s