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Effective synthesis and transformations of Alkyne betulin derivatives

✍ Scribed by O. B. Kazakova; E. Yu. Yamansarov; L. V. Spirikhin; M. S. Yunusov; I. P. Baikova; O. S. Kukovinets; R. Z. Musin

Book ID
111465658
Publisher
SP MAIK Nauka/Interperiodica
Year
2011
Tongue
English
Weight
204 KB
Volume
47
Category
Article
ISSN
1070-4280

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## Abstract Selective acetylation of 1 at C‐28 afforded the monoacetate 2, which was oxidized to the 3‐oxo compound 8. H,D exchange at C‐2 in 8 followed by reduction with LiAlH~4~ led to [2‐^2^H]‐betulin (5). Reduction of 8 with NaBD~4~ or LiAlD~4~ yielded [3‐^2^H]betulin (6) besides different amou