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Effect ofl-arginine on metabolism of polyamines in rat’s brain with extrahepatic cholestasis

✍ Scribed by Dušan Sokolovic; Gordana Bjelakovic; Jelenka Nikolic; Boris Djindjic; Dusica Pavlovic; Gordana Kocic; Ivana Stojanovic; Voja Pavlovic


Publisher
Springer
Year
2009
Tongue
English
Weight
259 KB
Volume
38
Category
Article
ISSN
0939-4451

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Pregnant rats were treated for five consecutive days during gestation with s.c. injections of the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO). Treatment beginning at gestational days 13 or 14 was effective in inhibiting ODC and altering polyamine levels, and resulted