Effect ofin vivo andin vitro degradation on molecular and mechanical properties of various low-molecular-weight polylactides

✍ Scribed by Mainil-Varlet, Pierre ;Curtis, Raymond ;Gogolewski, Sylwester

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 623 KB
• Volume: 36
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(19970905)36:3<360::aid-jbm11>3.0.co;2-i

✦ Synopsis

The in vivo and in vitro degradation of low-and poly(L/DL-lactide) samples subjected to in vitro degradamolecular-weight poly(L-lactide), poly(L/D-lactide), and poly tion tests in both the static and pseudodynamic modes are (L/DL-lactide) rods was investigated. The low-molecular-in good approximation with data obtained from the in vivo weight fast-degrading materials were used to accelerate the study. The pH of the buffer solution had no evident effect degradation process and make the test conditions more criti-on the mechanical properties or the rate of degradation as cal. In the in vivo study the rods were implanted in the soft estimated from the drop in molecular weight of the aged tissue of sheep and explanted at 1, 3, 6, and 12 months. In samples. The replacement of the aging buffer to maintain a the in vitro experiments the samples were subjected to aging constant pH at 7.4 does not seem to be critical for the degradaat 37ЊC in the phosphate buffer using two different modes.

tion of the polylactides. In vitro degradation tests can be used In the so-called pseudodynamic mode the aging buffer was as a relevant procedure for predicting the in vivo functionality regularly replaced if the pH dropped more than 0.5. In the of implants from the polylactides used if the criteria for static mode the buffer was not changed over the whole testing assessing such a functionality are the changes in mechanical period of 52 weeks. The mechanical, molecular, and crystal-properties and molecular weight.