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Effect of α-Ketoisocaproate and Leucine on the in Vivo Oxidation of Glutamate and Glutamine in the Rat Brain

✍ Scribed by H. Ronald Zielke; Yinyin Huang; Peter J. Baab; Roger M. Collins; Carol L. Zielke; J. Tyson Tildon

Book ID
111568620
Publisher
Springer
Year
1997
Tongue
English
Weight
592 KB
Volume
22
Category
Article
ISSN
0364-3190

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Hydrolysis of extracellular glutamine as a potential source of increased extracellular glutamate in the quinolinic acid (QUIN)-injured brain of the unanesthetized, free-moving rat was examined by microdialysis and HPLC analysis. Injury was initiated by injection of 100 nmoles of QUIN into the hippoc