Effect of whole blood and plasma on the permeability of glucose through different cellulose and cellulose acetate membranes

✍ Scribed by Lars Risinger; Thomas Buch-Rasmussen; Gillis Johansson

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 730 KB
• Volume: 231
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/s0003-2670(00)86415-6

✦ Synopsis

Model experiments were made wtth a flow-through dialysis cell to study how glucose m whole blood, plasma and aqueous standards IS transferred through different membranes. Detection was vta a glucose dehydrogenase reactton and NADH momtoring wtth a chemically modified electrode. The detector response was hnear wtth the glucose concentration m all cases. The non-Newtoman properties of whole blood seem to be of great importance for the response Theorettcal models are proposed both for the effect of plasma viscosity and the red cell volume fractton (haematocnt) dependence on the glucose transfer rate The models could only partially explam the differences between measurements m aqueous soluttons and body fluids. Better agreement and less haematocnt dependence were obtamed wtth low-permeabihty membranes.