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Effect of water-soluble carriers on morphine sulfate release from a silicone polymer

✍ Scribed by James W. McGinity; Louis A. Hunke; Alan B. Combs

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 322 KB
Volume: 68
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600680544

No coin nor oath required. For personal study only.

✦ Synopsis

chromatographically identical to methadone (80.5%). morphine (95.5?6), and naloxone ( 100%). 'I'otal extracted plasma radioactivity represented methadone (7G.(rb), morphine (75.5'M~), or naloxone (91.8'h). Parent drug extraction selectivity in each case was acceptable.

Timesaving is the greatest advantage of this method. Extraction of 20 t.issue samples required 10-15 min; 1.5-2 hr was required with standard liquid--liquid extraction. Since brain and plasma drug concentrations are routinely required in pharmacological studies, the utility of the present method is obvious. Theoretically, t he present procedure could be substituted for any organic, hase or acid solvent extraction from biological fluids and tissues.

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