Effect of viral status on recurrence after liver resection for patients with hepatitis B virus–related hepatocellular carcinoma
✍ Scribed by Shoji Kubo; Kazuhiro Hirohashi; Hiromu Tanaka; Tadashi Tsukamoto; Taichi Shuto; Takatsugu Yamamoto; Takashi Ikebe; Kenichi Wakasa; Shuhei Nishiguchi; Hiroaki Kinoshita
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 94 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
Risk factors for recurrence after resection of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) require more precise definition.
Methods:
Forty patients who underwent liver resection for hbv-related hcc were studied. their clinical findings, laboratory data (including viral status), pathologic findings, and operative methods were evaluated for recurrence risk in univariate and multivariate analyses.
Results:
The hb envelope (hbe) antigen, wild-type hbv, intrahepatic metastases, elevated serum activities of aspartate aminotransferase and alanine aminotransferase, and moderately or severely active hepatitis were more likely to be found in patients with a high viral load than in patients with a low viral load. precore mutant-type hbv was more likely to be found in patients with a low viral load than in patients with a high viral load. the platelet count was significantly lower in the patients with a high viral load. a high viral load, the presence of wild-type hbv, the absence of anti-hbe, the absence of precore mutant-type hbv, child score b, a low platelet count, and a positive surgical margin were risk factors for recurrence in univariate analysis. a nonanatomic resection tended to be a risk factor. a high viral load and positive surgical margin were independent risk factors for recurrence.
Conclusions:
The measurement of viral load and detection of anti-hbe, wild-type hbv, and precore mutant-type hbv are useful for estimating a patient's prognosis after resection of hbv-related hcc.