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Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy

✍ Scribed by A. T. McGown; D. Murphy; D. Crowther; B. W. Fox

Publisher
Springer
Year
1991
Tongue
English
Weight
293 KB
Volume
27
Category
Article
ISSN
0344-5704

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra