Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin
β Scribed by Dhruba J. Chatterjee; Wen Y. Li; Robert T. Koda
- Book ID
- 110309137
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 661 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0724-8741
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Squaric acid diethylester and squaric acid dibutylester have been used in contact sensitization therapy of alopecia areata. This study investigated the application of these esters or squaric acid alone to hairless mouse and human skin in vitro to determine squaric acid flux from the various preparat
## Abstract ## Background and Objectives ALA esters have been developed to improve PpIX production in ALAβPDT, but they do not perform as well in skin as they do in cells and the bladder. ## Study Design/Materials and Methods The in vitro penetration across normal mouse skin of ALA and its methy