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Effect of urine pH and flow on renal clearance of methotrexate

✍ Scribed by T. E. Sand; S. Jacobsen

Publisher
Springer
Year
1981
Tongue
English
Weight
521 KB
Volume
19
Category
Article
ISSN
0031-6970

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The pharmacokinetics of low dose methotrexate (MTX) were evaluated in 12 rheumatoid arthritis patients in the presence and absence of steady-state levels of salicylic acid (ASA) and sulindac (SU). Using a Latin square design, patients were given MTX plus ASA (mean 3.4 g/day), MTX plus SU (mean 400 m