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Effect of two inducers of cellular differentiation on the glutathione status of human HL-60 promyelocytic leukaemia and A549 lung carcinoma cells

โœ Scribed by Charles M. Lazenby; Andreas Gescher; Ian L. Dale


Book ID
115779644
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
314 KB
Volume
36
Category
Article
ISSN
0006-2952

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I 2-0-tetradecanoylphorbol-I 3-acetate (TPA) and bryostatin I are activators of protein kinase C (PKC). TPA is a potent inhibitor of the growth of A549 cells, while bryostatin I exerts a weak antiproliferative effect upon this cell line. We tested the hypothesis that the PKC inhibitor staurosporine