Effect of two gold compounds on human polymorphonuclear leukocyte lysosomal function and phagocytosis
✍ Scribed by Stephanus H. Kühn; M. Beatrice Gemperli; Frederick C. Beer
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 307 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0360-3997
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## Abstract The effects of 2‐deoxyglucose (DOG), an inhibitor of glycolysis, on guinea pig polymorphonuclear leukocytes (PMN) obtained from peritoneal exudates was examined. ATP levels in PMN were reduced by 40% by one hour following an incubation with 2‐deoxyglucose. When complement (C3) coated ^1
## Abstract 2‐Deoxyglucose transport was characterized in human polymorphonuclear leukocytes (PMN) and rabbit alveolar macrophages (AM). The Km was 1 mM for human PMN and 1.6 mM for rabbit AM, and the Vmax was 0.66 × 10^−3^ μmoles/45 sec/10^6^ PMN and 5.09 × 10^−4^ μmoles/45 sec/10^6^ AM. The rate