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Effect of transganglionic degenerative atrophy on opiate receptors in the dorsal horn of the spinal cord

✍ Scribed by B. Csillik; J. Kiss; Elizabeth Knyihar-Csillik; Dr. A. Lajtha

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 460 KB
Volume: 8
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490080411

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We investigated alterations in opiate‐binding sites in the upper dorsal horn after transection of the related peripheral sensory nerve in rats. The binding of (^3^H)diprenorphine was measured autoradiographically. The findings indicated a shift of the binding sites, rather than a degenerating disappearance, with a decrease in nerve fibers but an increase in nerve cells. This may be due to latent opiate‐binding sites becoming manifest.

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