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Effect of tordon 2,4-D 64/240 triethanolamine BR on the energy metabolism of rat liver mitochondria

✍ Scribed by Luiz Fernando Pereira; Annibal P. Campello; Orieta Silveira

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 542 KB
Volume: 14
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550140105

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✦ Synopsis

Tordon herbicide, which is a mixture of 4-amino-3,5,6-trichloropicolinic acid (picloram) and 2,4-dichlorophenoxyacetic acid (2,4-D), depresses the phosphorylation efficiency of the rat liver mitochondria, as inferred from the decrease of the respiratory control coefficient and the ADP/O ratios when NAD+-dependent substrates were used; NADH oxidase and NADH cytochrome c reductase were also inhibited, without any effect on the other enzymatic complexes of the respiratory chain. Tordon (66.2 nmol picloram + 270 nmol 2,4-D mg-' protein) affected the amplitude of swelling induced by glutamate, succinate,(N,N,N,phenyldiamine + sodium ascorbate and ATP. These results characterize an interaction of Tordon with complex I of the respiratory chain and also a partial collapse of the proton motive force of the mitochondrial inner membrane without affecting its elasticity.

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