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Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury

✍ Scribed by Seki, Hiroyuki (author);Tasaka, Sadatomo (author);Fukunaga, Koichi (author);Shiraishi, Yoshiki (author);Moriyama, Kiyoshi (author);Miyamoto, Keisuke (author);Nakano, Yasushi (author);Matsunaga, Naoko (author);Takashima, Katsunori (author);Matsumoto, Tatsumi (author);Ii, Masayuki (author);Ishizaka, Akitoshi (author);Takeda, Junzo (author)

Publisher: SP Birkhäuser Verlag Basel
Year: 2010
Tongue: English
Weight: 410 KB
Volume: 59
Category: Article
ISSN: 1420-908X
DOI: 10.1007/s00011-010-0195-3

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## Abstract Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro‐inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are