Effect of theophylline on corticorenal contents of some aminoglycosides in the rat
β Scribed by D. Capone; N. Pisanti; V. De Marino; A. Gentile; G. Schettini; A. Marino
- Book ID
- 114075491
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 84 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0031-6989
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The effect of domperidone (2 mg kg-') on the pharmacokinetics of a single oral dose of theophylline (25 mg kg-') was studied in the rat. Theophylline concentrations were measured serially for 12 h using an HPLC technique. Domperidone did not have any significant effect on any of the four parameters
The immediate and delayed effects of chloroquine on theophylline kinetics were investigated in rats pretreated with chloroquine diphosphate (45 mg kg -1 ) or saline intraperitoneally. One hour or 4 days after chloroquine, theophylline (10 mg kg -1 ) was administered intravenously. Compared with the