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Effect of the β-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases

✍ Scribed by Lauren Oleson; Michael H. Court

Book ID
111770876
Publisher
Pharmaceutical Press
Year
2008
Tongue
English
Weight
376 KB
Volume
60
Category
Article
ISSN
2042-7158

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Valproic acid glucuronidation kinetics were carried our with three human UGT isoforms: UGT1A6, UGT1A9, and UGT2B7 as well as human liver and kidney microsomes. The glucuronidation of valproic acid was typified by high K(m) values with microsomes and expressed UGTs (2.3-5.2mM). The ability of valproi