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Effect of the tyrosine kinase inhibitor lapatinib on CUB-domain containing protein (CDCP1)-mediated breast cancer cell survival and migration

✍ Scribed by Jeanette Seidel; Klaudia Kunc; Kurt Possinger; Christian Jehn; Diana Lüftner


Book ID
116302384
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
828 KB
Volume
414
Category
Article
ISSN
0006-291X

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Breast cancers frequently over-express a number of growth factor receptors. In addition, elevated src family kinase activity is present in a percentage of these neoplasms and has been implicated in signal transduction in these cells. Therefore, inhibiting tyrosine kinase activity is a potential appr