Effect of the pH grade of silicates on chemical stability of coground amorphous quinapril hydrochloride and its stabilization using pH-modifiers

Solid-state surface acidity and pH-stabi

Solid-state surface acidity and pH-stability profiles of amorphous quinapril hydrochloride and silicate formulations

✍ Shumet A. Hailu; Robin H. Bogner 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 1 views

To determine the surface acidity and stability profiles of quinapril hydrochloride (QHCl) coground with silicates, solid-state equivalent pH (pHeq) of amorphous samples was measured by diffuse reflectance spectroscopy using pH indicator probes. Calibration curves for pH indicators were developed in