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Effect of the N-terminal sequence on the binding affinity of transthyretin for human retinol-binding protein

✍ Scribed by Ladda Leelawatwattana; Verayuth Praphanphoj; Porntip Prapunpoj


Book ID
111314041
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
407 KB
Volume
278
Category
Article
ISSN
1432-1327

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The synthetic retinoid 4-HPR has been shown to markedly lower the plasma concentration of both retinol and RBP in rats and humans. We have studied the effect of 4-HPR on the secretion of retinol-RBP from liver cells in vivo and in vitro. In rats maintained with a normal diet, a vitamin A-deficient d