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EFFECT OF THE IMPase INHIBITOR L690,330 ON SEA URCHIN DEVELOPMENT

✍ Scribed by GABIELLA SCONZO; DOMENICO CASCINO; GABRIELE AMORE; FABIANA GERACI; GIOVANNI GIUDICE

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
221 KB
Volume
22
Category
Article
ISSN
1065-6995

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✦ Synopsis

A variety of concentrations of the IMPase inhibitor L690,330 were added to sea urchin embryos. Immediate arrest of development was obtained for concentrations from 7.5 mm on. Concentrations lower than 3.5 mm permitted gastrulation but inhibited skeletogenesis and disturbed elongation along the animal-vegetal axis. The latter results are similar to those obtained by counteracting lithium effect with myoinositol, which are suggested to be due to partial relief of IMPase inhibition.

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