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Effect of the chronic combined administration of cisplatin and paclitaxel in a rat model of peripheral neurotoxicity

✍ Scribed by Valentina Carozzi; Alessia Chiorazzi; Annalisa Canta; Norberto Oggioni; Alessandra Gilardini; Virginia Rodriguez-Menendez; Federica Avezza; Luca Crippa; Cecilia Ceresa; Gabriella Nicolini; Mario Bossi; Guido Cavaletti

Book ID
116429872
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
870 KB
Volume
45
Category
Article
ISSN
0959-8049

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Cardiotoxicity of doxorubicin/paclitaxel
Cardiotoxicity of doxorubicin/paclitaxel combination in rats: Effect of sequence and timing of administration
✍ Sherif Y. Saad; Tawfeeg A. O. Najjar; Mouied Alashari 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB

## Abstract The higher incidence of cardiotoxicity of doxorubicin (DOX)/paclitaxel (PTX) combination compared with DOX alone remains to be a major obstacle against effective chemotherapeutic treatment. We investigated the effect of sequence and time interval between administration of both drugs on