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Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A

✍ Scribed by Kirsi Piippo; Sam Holmström; Heikki Swan; Matti Viitasalo; Marja Raatikka; Lauri Toivonen; Kimmo Kontula


Book ID
113974616
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
267 KB
Volume
87
Category
Article
ISSN
0002-9149

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A de novo missense mutation (R1623Q) of
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Two missense mutations and a nine-nucleotide deletion of the cardiac sodium channel (SCN5A) gene have been shown to cause long QT syndrome (LQTS) in sev eral familial cases. We identified a novel missense mutation (R1623Q) of the SCN5A gene in a Japanese girl with sporadic LQTS. We used polymerase c