Effect of the 21-aminosteroid, U-74389F, on hyperoxic lung injury in rats
✍ Scribed by I. M. Richards; R. L. Griffin; S. F. Fidler; E. J. Jacobsen
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1993
- Tongue
- English
- Weight
- 194 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1420-908X
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📜 SIMILAR VOLUMES
## Abstract The effects of U‐74006F (tirilazad mesylate), a 21‐aminosterold antioxidant, on injured peripheral nerve were studied. Twenty‐two immature and 44 mature rats were divided equally into two groups. The experimental group received two injections of 3 mg/kg of U‐74006F at a 2 hour interval.
Respiratory viral infections have been associated with exacerbations of asthma in humans, and are known to produce airway obstruction and hyperresponsiveness in rats. Virus-induced airway dysfunction may result in part from inflammatory cells and their products, and agents that target these mechanis