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Effect of thalamotomy on focal hand dystonia in a family with DYT1 mutation

✍ Scribed by Mi J. Kim; Sang R. Jeon; Han-Wook Yoo; Gu-Hwan Kim; Myoung C. Lee; Sun J. Chung

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
225 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We report the clinical and molecular features of a family with focal hand dystonia caused by DYT1 mutation. Four members of a family who underwent thalamotomy showed a marked and sustained therapeutic benefit that lasted for up to 12 years without recurrence of dystonia or any significant surgical complication. The hand dystonia caused by DYT1 mutation may be successfully managed by thalamotomy. © 2008 Movement Disorder Society

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