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Effect of TGF-β and TNF-α on apoptosis and proliferation of liver myofibroblasts (RMF) and activated hepatic stellate cells (HSC)

✍ Scribed by B. Saile; N. Matthes; G. Ramadori

Book ID
119526000
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
159 KB
Volume
32
Category
Article
ISSN
0168-8278

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Transforming growth factor β and tumor n
Transforming growth factor β and tumor necrosis factor α inhibit both apoptosis and proliferation of activated rat hepatic stellate cells
✍ Bernhard Saile; Nina Matthes; Thomas Knittel; Giuliano Ramadori 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

Transforming growth factor ␤ (TGF-␤) as well as tumor necrosis factor ␣ (TNF-␣) gene expression are up-regulated in chronically inflamed liver. These cytokines were investigated for their influence on apoptosis and proliferation of activated hepatic stellate cells (HSCs). Spontaneous apoptosis in ac