Effect of temperature on the survival of hepatitis A virus and its capsidal antigen in synthetic seawater

✍ Scribed by Crance, J. M. ;Gantzer, C. ;Schwartzbrod, L. ;Deloince, R.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 75 KB
• Volume: 13
• Category: Article
• ISSN: 1053-4725
• DOI: 10.1002/(sici)1098-2256(1998)13:1<89::aid-tox7>3.0.co;2-3

✦ Synopsis

The aim of this work is to study the variation of the infectious titer and the hepatitis A virus ( ) HAV antigen titer at 4, 19, and 25ЊC following artificial contamination in sterile seawater. The results show that the survival of infectious HAV depends greatly on the temperature parameter. The T are 11 90 days at 25ЊC and 24 days at 19ЊC, and the infectious titer remains stable at 4ЊC throughout the 92 day duration of the experiment. The capsidal antigen is found to survive much longer in seawater than the infectious virus. Indeed the T was estimated to be 19 times greater at 19ЊC and 7 times greater at 25ЊC 90 for the capsidal antigen. The capsidal antigen constitutes a marker that allows detection of the presence of HAV in seawater, although it has very low sensitivity and does not provide any information on the infectious characteristics of the virus. Indeed at 19 and 25ЊC the antigen survives much longer than the infectious virus.