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Effect of tamoxifen on extracellular signal-regulated kinases in the urethra of castrated female rats

✍ Scribed by Alesse R. dos Santos; Pedro V. Lopes-Costa; José A. Gontijo; Benedito B. da Silva

Book ID
119234328
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
223 KB
Volume
164
Category
Article
ISSN
0301-2115

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The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-