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Effect of tamoxifen and 2-methoxyestradiol alone and in combination on human breast cancer cell proliferation

✍ Scribed by H. Seeger; D. Diesing; B. Gückel; D. Wallwiener; A.O. Mueck; J. Huober

Book ID: 117668482
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 92 KB
Volume: 84
Category: Article
ISSN: 0960-0760
DOI: 10.1016/s0960-0760(03)00037-2

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## Abstract 2‐Methoxyestradiol, a well‐known nonpolar endogenous metabolite of 17β‐estradiol, has been shown to selectively induce apoptosis in a number of cancer cell lines, but not in normal cells. The mechanism of 2‐methoxyestradiol‐induced apoptosis appears to vary considerably in different cel