Pharmacokinetic and immunosuppressive ef
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Yasunori Miyamoto; Takeji Uno; Hiromitsu Yamamoto; Li Xiao-Kang; Koh-ichi Sakamo
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Article
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2004
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John Wiley and Sons
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English
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The objective of this study was to characterize the pharmacokinetics and immunosuppression of a tacrolimusloaded biodegradable microsphere (TLBM) in rats. We prepared TLBM. DA/Slc rats were given TLBM at a dose of 1.6 mg/kg (n โซุโฌ 9), 2.4 mg/kg (n โซุโฌ 5), or 7.2 mg/kg (n โซุโฌ 7) tacrolimus contents b