Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures
β Scribed by Seung-Mi Kang; Ji-Yun Min; Yong-Duck Kim; Dong-Jin Park; Ha-Na Jung; Chandrakant S. Karigar; Yeong-Lae Ha; Seon-Won Kim; Myung-Suk Choi
- Book ID
- 118471498
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 171 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0168-1656
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## Abstract This study investigated the potential neuroprotective effects of the __Ginkgo biloba__ extract, EGbβ761, and ginkgolide B, on adrenalectomy (ADX)βinduced cell death in the dentate gyrus (DG). Adrenalectomised, sham surgeryβtreated, and naive controls received either EGbβ761 (25, 50, or
The effects of repeated (15-day) oral treatments with an extract of Ginkgo biloba (EGb 761; 50 mg/kg/day) or with its terpenoid constituent, bilobalide (2 mg/kg/day), were assessed in normal rats and in rats that had been previously injected with streptozotocin (50 mg/kg, i.p. in saline solution), a