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Effect of study protocol on the interactions between cimetidine and paracetamol in man

✍ Scribed by M. Garba; M. T. Odunola; B. H. Ahmed

Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
487 KB
Volume
24
Category
Article
ISSN
0378-7966

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Plasma and urine concentrations of codeine and its measurable metabolites were determined by HPLC in six healthy subjects after a single 30 mg oral dose of codeine either alone or after 7 doses of 1 g paracetamol 8 hourly. After codeine alone, the t1/2 (h), AUC (mumol.l-1.h) and CLR (ml.min-1) for c