Effect of stem cell factor (c-kit ligand), granulocyte-macrophage colony stimulating factor and interleukin 3 on hematopoietic progenitors in human long-term bone marrow cultures
✍ Scribed by Roberto M. Lemoli; Dr. Subhash C. Gulati
- Book ID
- 112212499
- Publisher
- AlphaMed Press
- Year
- 1993
- Tongue
- English
- Weight
- 912 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1066-5099
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The hematopoietic system in patients with aplastic anemia (AA) shows both quantitative and qualitative deficiencies, i.e., reduced numbers of hematopoietic progenitor cells (HPC) and impaired HPC proliferation in long-term marrow cultures (LTMC). Since recombinant human granulocyte macrophage-colony
## Abstract The roles of colony‐stimulating factors in long‐term bone marrow cultures were studied and compared. After single additions of high concentrations of unpurified colony‐stimulating activities to the cultures, rapid deterioration of the cultures was observed. This appears to result from c
## Background: Interleukin-3 (il-3) and granulocyte-macrophage-colony stimulating factor (gm-csf) have synergistic, hematopoietic growth-promoting activity in preclinical studies. because of the paucity of effective therapies for patients with chronic bone marrow failure states, the authors studied