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Effect of statins on the proteasomal activity in mammalian endothelial and vascular smooth muscle cells

โœ Scribed by Antje Ludwig; Britt Friedel; Susanne Metzkow; Silke Meiners; Verena Stangl; Gert Baumann; Karl Stangl


Book ID
113487622
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
444 KB
Volume
70
Category
Article
ISSN
0006-2952

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Myocardin is a transcriptional co-activator of serum response factor (SRF) and can be degraded through ubiquitin-proteasome system. Our preliminary studies unexpectedly revealed that accumulation of myocardin in response to proteasome inhibition by MG132 or lactacystin resulted in decrease of transc