Effect of splenectomy upon the growth of B16-F10 melanoma and its relation to the interferon system

✍ Scribed by Howard L. Stoll III; Dr. Kailash C. Chadha

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 530 KB
• Volume: 40
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930400204

✦ Synopsis

The influence of splenectomy upon the growth of B16-F10 malignant melanoma and changes in interferon-synthesizing ability in mice were studied. Surgical stress alone temporarily diminished the ability of mice to respond to interferon induction by poly rIrC. Two weeks following the surgery, mock-splenectomized mice fully regained their interferon synthesis ability. However, this was not true in the case of splenectomized mice. They remained refractory to interferon induction. The removal of the spleen had no obvious effect on the rate of pulmonary metastasis in mice injected with B16-F10 malignant melanoma in relation to the mock-splenectomized or control mice. Mice that were splenectomized and inoculated with B16-F10 melanoma also remained refractory to interferon induction.