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Effect of solvents and effect of nucleophiles in nucleophilic substitution on benzyl bromide—A kinetic study

✍ Scribed by P. Manikyamba; E. V. Sundaram

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
611 KB
Volume
22
Category
Article
ISSN
0538-8066

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✦ Synopsis

Abstract

The kinetics of the reaction of benzyl bromide with thiourea was studied in different pure (protic and aprotic) solvents and the rate data was correlated using linear multiple regression analysis. From the regression coefficients which describe the susceptibility of rate to different solvent parameters, information regarding the solvent‐reagent, and the solvent‐intermediate interactions was obtained and solvation models were proposed.

Applicability of the Swain‐Scott free energy relationship was tested using different sulphur nucleophiles in acetonitrile solvent and the nucleophilicity constant of N‐acetylthiourea was computed as 2.74 from the regression line.

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