Effect of soluble complement receptor type 1 on porphyrin-induced phototoxicity in guinea pigs

✍ Scribed by Nakao Nomura; Henry W. Lim; James L. Levin; Shigeru Sassa

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 384 KB
• Volume: 42
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/s1011-1344(97)00112-7

✦ Synopsis

The effect of recombinant human soluble complement receptor type I (sCR1) on the porphyrin-mediated phototoxic reaction was evaluated i n guinea pigs. Phototoxicity was induced i n the animals by intraperitoneal injection of hematoporphyrin derivative (HpD),

followed by irradiation at a wavelength range of 32W50 nm. sCR1 administration decreased CH50 titers in a dose-dependent fashion, while it only moderately suppressed HpD/radiation-induced ear swelling at a high dose. These findings suggest that pholotoxic dermatological changes in cutaneous porphyrias are not solely due to complement activation.