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Effect of size at the nanoscale and bilayer rigidity on skin diffusion of liposomes

✍ Scribed by Sundar Babu; Chenxiang Fan; Leonard Stepanskiy; Jouni Uitto; Elisabeth Papazoglou

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 231 KB
Volume: 91A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.32197

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✦ Synopsis

Abstract

This study reports the effect of liposome particle size at the nanoscale and bilayer deformability on the permeation through MatTek human skin equivalents and provides a comparative quantitative measure through calculation of diffusion coefficients. Exploring DOPC and DPPC fluorescent liposomes, our results demonstrate the faster diffusion of 50 nm liposomes compared with 100 and 200 nm liposomes when the lipid bilayer remains the same. Diffusion kinetics of the 50 nm particles appear not to depend on the rigidity of the lipid layer, whereas diffusion of particles larger than 100 nm is significantly affected by the rigidity of the bilayer, and DOPC liposomes diffuse faster than their DDPC equivalents. Our results suggest that liposomes composed of a rigid bilayer can be expected to remain intact after passing through the stratum corneum. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

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