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Effect of single ascending, supratherapeutic doses of sparfloxacin on cardiac repolarization (QTc interval)

✍ Scribed by Joel Morganroth; George H. Talbot; Mary B. Dorr; Robert D. Johnson; William Geary; David Magner


Book ID
117322301
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
705 KB
Volume
21
Category
Article
ISSN
0149-2918

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o