Effect of single and multiple administration of an O 6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

Effect of O6-(4-bromothenyl)guanine on d

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

✍ Mark R. Middleton; Nicholas Thatcher; T. Brian H. McMurry; R. Stanley McElhinney 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 70 KB

## Abstract The DNA repair protein __O__^6^‐alkylguanine DNA alkyltransferase (ATase) is a major component of resistance to treatment with methylating agents and nitrosoureas. Inactivation of the protein, __via__ the administration of pseudosubstrates, prior to chemotherapy has been shown to improv