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Effect of Silymarinphospholipid Complex on the Liver in Rabbits Maintained on a High-fat Diet

✍ Scribed by M. Droździk; S. Juźwiak; A. Machoy-Mokrzyńska; J. Wójcicki; M. Kałdońska; Z. Myśliwiec; Z. Juzyszyn; J. Skowron; L. Rózewicka; A. Mścisz; P. Gorecki

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
628 KB
Volume
10
Category
Article
ISSN
0951-418X

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✦ Synopsis

Fifty mongrel rabbits were divided into five equal groups: (1) controls, (2) animals receiving a high-fat diet (HFD), containing cholesteral and coconut oil, (3) HFD + silymarin, (4) HFD + lecithin (L), and (5) HFD + silymarinphospholipid complex (SPC). The experiment lasted 12 weeks. Histopathological alterations due to exposure to HFD were the least advanced in a group of animals maintained on HFD + SPC, compared with group 3 and group 4, and were near normal. A beneficial effect of SPC is most probably due to combined antioxidant (reduction of MDA concentration) and metabolic (fall in cholesterol content in liver homogenate and liver microsomes) properties.

These findings suggest that SPC may be an effective agent in the protection against liver damage induced by a high-fat diet.

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