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Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery

โœ Scribed by O Pauvert; C Lugnier; T Keravis; R Marthan; E Rousseau; J P Savineau


Book ID
110007814
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
218 KB
Volume
139
Category
Article
ISSN
0007-1188

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The effect of regucalcin, a calcium-binding protein isolated from rat liver cytosol, on Ca2+/calmodulin-dependent cyclic nucleotide (AMP) phosphodiesterase activity in rat liver cytosol was investigated. The addition of Ca2+ (50 microM) and calmodulin 160 U/ml in the enzyme reaction mixture caused a