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Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants

✍ Scribed by K. S. Murthy; J. C. Samyn


Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
457 KB
Volume
66
Category
Article
ISSN
0022-3549

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## Abstract ## BACKGROUND Chronic myelogenous leukemia (CML) is characterized by a molecular aberration, a fusion __BCR‐ABL__ gene encoding for aberrant tyrosine kinase activity, which is crucial in the pathogenesis of CML. In vitro, inhibition of BCR‐ABL protein tyrosine kinase activity by a tyro