Effect of serum from cardiovascular patients on catalytic activity of secretory phospholipase A2(IIA)
β Scribed by E. V. Samoilova; A. A. Pirkova; N. V. Prokazova; A. A. Korotaeva
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 257 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0007-4888
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## Abstract It is well known that the expression level of secretory group IIA phospholipase A~2~ (sPLA~2~βIIA) is elevated in inflammatory diseases and lipopolysaccharide (LPS) upβregulates the expression of sPLA~2~βIIA in human umbilical vein endothelial cells (HUVECs). Recently, lower concentrati
Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi