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Effect of semiconductor GaAs laser irradiation on pain perception in mice

✍ Scribed by Neven Žarković; Hari Manev; Danka Peričić; Karolj Skala; Mislav Jurin; Anton Peršin; Milan Kubović

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
390 KB
Volume
9
Category
Article
ISSN
0196-8092

No coin nor oath required. For personal study only.

✦ Synopsis

The influence of subacute exposure (11 exposures within 16 days) of mice to the low power (GaAs) semiconductive laser-stimulated irradiation on pain perception was investigated. The pain perception was determined by the latency of foot-licking or jumping from the surface of a 53°C hot plate.

Repeated hot-plate testing resulted in shortening of latencies in both sham-and laser-irradiated mice. Laser treatment (wavelength, 905 nm; frequency, 256 Hz; irradiation time, 50 sec; pulse duration, 100 nsec; distance, 3 cm; peak irradiance, 50 W/cm2 in irradiated area; and total exposure, 0.41 mJ/cm2) induced further shortening of latencies, suggesting its stimulatory influence on pain perception.

Administration of morphine (20 mgkg) prolonged the latency of response to the hot plate in both sham-and laser-irradiated mice. This prolongation tended to be lesser in laser-irradiated animals.

Further investigations are required to elucidate the mechanism of the observed effect of laser.

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