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Effect of Selective Ablation of Proliferating Mammary Epithelial Cells on MNU Induced Rat Mammary Tumorigenesis

โœ Scribed by Lakshmi Sivaraman; Jason Gay; Susan G Hilsenbeck; H David Shine; Orla M Conneely; Daniel Medina; Bert W O'Malley

Book ID
110334714
Publisher
Springer US
Year
2002
Tongue
English
Weight
351 KB
Volume
73
Category
Article
ISSN
0167-6806

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Mammary tumors were induced in 48-52-day-old female Sprague-Dawley rats in metestrus or diestrus with a single jugular injection of MNU (50 mg/kg). Control rats received the saline vehicle (Group 4 n ฯญ 9). Rats were fed 4% Teklad diet containing either 0 (Group 3, n ฯญ 20) or 782 mg 4-HPR/kg diet. 4-